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Title: Antioxidant effect of eugenol in rat intestine
Authors: Vidhya, N
Devaraj, S Niranjali
Issue Date: Dec-1999
Publisher: NISCAIR-CSIR, India
Abstract: The effect of eugenol on the antioxidant status of the rat intestine after short and long term (15 days and 90 days, respectively) oral administration of 1000 mg/kg.b.wt (a dosage which has been reported to be highly hepatoprotective)1 was studied. The level of lipid peroxidation products (TBARS) and the activities of glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) were found to be near normal on eugenol treatment. The level of glutathione (GSH) did not show any change on 15 days of eugenol treatment, but it was increased significantly on 90 day eugenol treatment. The activit y of glutathione-S-transferases (GSTs) was increased significantly in both 15 day eugenol treated and 90-day eugenol treated groups. The results suggest that eugenol is nontoxic, protective and induces, glutathione-S-transferases (GSTs) and thereby it may facilitate the removal of toxic substances from the intestine.
Page(s): 1192-1195
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.37(12) [December 1999]

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