NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(06) [June 2008] >

Title: Quantitative structure-activity relationship studies of a new class of selective aldose reductase inhibitors
Authors: Sharma, R
Sahoo, P K
Chaturvedi, S C
Keywords: Benzimidazol
Aldose reductase activity
Quantitative Structure-Activity Relationship
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Quantitative structure activity relationship studies on a series of [1,2,4]Triazino[4,3-a] benzimidazole acetic acid derivatives with selective aldose reductase inhibitor activity is made using a combination of various physicochemical descriptors. This is a new class of triazino benzimidazole derivatives having selective activity with minimum toxic effects. Several significant equations with good co-efficient of correlation (≥ 0.854) are obtained; the best model is selected using predictive ability of equations. The model shows positive contribution of logP towards biological activity i.e., high hydrophobic nature of the molecules might be increasing the selective aldose reductase inhibitor activity.
Page(s): 957-962
ISSN: 0376-4699
Source:IJC-B Vol.47B(06) [June 2008]

Files in This Item:

File Description SizeFormat
IJCB 47B(6) 957-962.pdf159.45 kBAdobe PDFView/Open
 Current Page Visits: 57 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 135020 since 01-Sep-2015  Last updated on 27-May-2016Webmaster: