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Title: Quantitative structure-activity relationship studies of a new class of selective aldose reductase inhibitors
Authors: Sharma, R
Sahoo, P K
Chaturvedi, S C
Keywords: Benzimidazol;Aldose reductase activity;Quantitative Structure-Activity Relationship
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Quantitative structure activity relationship studies on a series of [1,2,4]Triazino[4,3-a] benzimidazole acetic acid derivatives with selective aldose reductase inhibitor activity is made using a combination of various physicochemical descriptors. This is a new class of triazino benzimidazole derivatives having selective activity with minimum toxic effects. Several significant equations with good co-efficient of correlation (≥ 0.854) are obtained; the best model is selected using predictive ability of equations. The model shows positive contribution of logP towards biological activity i.e., high hydrophobic nature of the molecules might be increasing the selective aldose reductase inhibitor activity.
Page(s): 957-962
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(06) [June 2008]

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