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|Title:||Chemical constituents of Dendrobium gratiosissimum and their cytotoxic activities|
|Keywords:||Cytotoxic activity;Bibenzyl derivative;Dendrobium gratiosissimum;Dengraol A, B;HL-60 cell;Orchidaceae|
|Abstract:||Two new bibenzyl derivatives, named dengraols A 1 and B 2, are isolated from stems of Dendrobium gratiosissimum Rchb. (Orchidaceae), together with seven known compounds: 3,5,4′-trihydroxybibenzyl 3, 3,4′-dihydroxy- 5-methoxybibenzyl 4, 3, 4 - dihydroxy-5, 4′ - dimethoxy bibenzyl 5, 3, 4′ - dihydroxy - 4, 5, 3′-trimethoxybibenzyl (moscatilin) 6 and 5, 4′- dihydroxy -3, 3′- dimethoxybibenzyl (gigantol) 7, 5, 3′, 4′-trihydroxy - 3- methoxybibenzyl (tristin) 8 and 5, 3′- dihydroxy- 3-methoxybibenzyl (batatasin III) 9. Among the isolated compounds, dengraols A 1 and B 2, moscatilin 6 and gigantol 7 showed inhibitory activity of proliferation on HL-60 cells with IC₅₀ values at 2.1, 6.4, 0.082 and 10.6 μM, respectively.|
|Appears in Collections:||IJC-B Vol.47B(06) [June 2008]|
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