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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(06) [June 2008] >
| Title: | Pachycanthine: A new isoquinoline alkaloid and its antihepatotoxic activity from Berberis pachycantha Koehne |
| Authors: | Ahmed, Bahar
Masoodi, Mubashir H
Khan, Shamshir |
| Keywords: | Berberis pachycantha
Antihepatotoxic activity
Isoquinoline alkaloids
Pachycanthine
Silymarin |
| Issue Date: | Jun-2008 |
| Publisher: | CSIR |
| Abstract: | The methanolic extract of whole plant of Berberis pachycantha Koehne (Berberidaceae) has afforded a new isoquinoline alkaloid, which was characterized as 8,9-dimethoxy-5,6,12a,6a-tetrahydro-2H-1,3-dioxoleno[4,5-g] isoquinolino [3,2-a] isoquinoline on the basis of spectral and chemical studies and has been designated as pachycanthine 1. The pachycanthine 1 exhibited a significant antihepatotoxic activity by 25-53% (dose: 50 mg/kg) with respect to standard silybon-70 (36-60%) against CClâ‚„ induced toxicity in Albino Wistar rats. |
| Page(s): | 945-951 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(06) [June 2008]
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