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IJC-B Vol.47B [2008] >
IJC-B Vol.47B(06) [June 2008] >


Title: Synthesis and study of some compounds containing oxazolone ring, showing biological activity
Authors: Tandel, R C
Mammen, Denni
Keywords: Phenyloxazol-5-one
Benzoyl glycine
Antibacterial activity
Antifungal activity
Seed germination
Liquid crystalline property
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Synthesis of the oxazolone ring has been performed by the condensation of 4-substituted alkoxy benzoyl glycine with appropriate 4-substituted alkoxy benzaldehyde, in the presence of acetic anhydride and anhydrous sodium acetate. The antibacterial activity has been checked against Micrococcus luteus and Escherichia coli and antifungal activity against Alternaria alternate and Phoma multirostata for all the compounds. The cytotoxicity has been checked against the monocots barley seeds; Hordeum vulgare L and dicots moong seeds; Phaseolus aureus. The compounds having electron releasing group exhibit antibacterial activity. Compounds with nitro group cause total inhibition of seed germination, exhibiting cytotoxic behaviour. The structures of the synthesized compounds have been characterized by elemental analysis and spectral data and the purity of the compounds has been checked by TLC method.
Page(s): 932-937
ISSN: 0376-4699
Source:IJC-B Vol.47B(06) [June 2008]

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