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Title: Microwave studies on synthesis of biologically active chalcone derivatives
Authors: Katade, Sushama
Phalgune, Usha
Biswas, Sujata
Wakharkar, Radhika
Deshpande, Nirmala
Keywords: Antimicrobial activity;Chalcones;Pyrazole
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Synthesis of pyrazole derivative using microwave energy has been carried out. The compound 1-[4-(2-hydroxy-ethoxy)-phenyl]-ethanone, is prepared from p-hydroxy-acetophenone and 2-chloro-ethanol. Chalcone derivative has been prepared by the condensation reaction of 1-[4-(2-hydroxy-ethoxy)-phenyl]-ethanone with 4-chlorobenzaldehyde. This chalcone derivative cyclised with hydrazine hydrate and glacial acetic acid under microwave irradiation conditions give pyrazole derivative. These products have been characterized by detailed spectral analysis and have been screened for their antimicrobial activity, against Escherichia coli, Proteus vulgaris, and Salmonella typhimurium.
Page(s): 927-931
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(06) [June 2008]

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