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IJC-B Vol.47B(06) [June 2008] >


Title: Synthesis of ureidopeptides using pentafluorophenyl carbamates from Nα-Fmoc-peptide acids
Authors: Sureshbabu, Vommina V
Venkataramanarao, Rao
Keywords: Curtius rearrangement
Peptide isocyanate
Pentafluorophenyl carbamate
Peptidyl
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Highly active and shelf stable pentafluoro phenol derived Fmoc-peptidyl carbamates have been synthesized from corresponding Fmoc-peptidyl isocyanates. The utility of pentafluorophenyl carbamate intermediates has been demonstrated by the synthesis of tri, penta and hexapeptidyl ureas which are obtained in good yields. All the synthesised compounds have been characterized by ¹H NMR, ¹³C NMR and mass spectroscopy. The coupling reaction using pentafluorophenyl carbamates to insert urea bond between α amino acids is fast, clean and high yielding.
Page(s): 910-919
ISSN: 0376-4699
Source:IJC-B Vol.47B(06) [June 2008]

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