Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/17409
Title: Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice
Authors: Sharma, Mukesh Kumar
Kumar, Madhu
Kumar, Ashok
Issue Date: Sep-2002
Publisher: NISCAIR-CSIR, India
Abstract: HgCl2 (5.0 mg/kg body weight) induced toxicity led to significant elevation of lipid peroxidation (LPO) level but decline in the glutathione content in liver of Swiss albino mice. In serum of  HgCl2 treated mice there was significant elevation in serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) activities but significant decline in the alkaline phosphatase activity. Animals treated with O. sanctum extract (10 mg/kg body weight, po) before and after mercury intoxication showed a significant decrease in LPO level , SGOT and SGPT activities and increase in serum alkaline phosphatase activity and glutathione (GSH) content. Ocimum treatment alone did not alter SGOT, SGPT and alkaline phosphatase activities but significantly enhanced reduced glutathione. The results suggest that oral administration of Ocimum  extract provides protection against HgCl­2 induced toxicity in Swiss albino mice.
Page(s): 1079-1082
URI: http://hdl.handle.net/123456789/17409
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(09) [September 2002]

Files in This Item:
File Description SizeFormat 
IJEB 40(9) 1079-1082.pdf987.09 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.