NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(06) [June 2008] >


Title: Theoretical studies on the initiation of alkylation pathway by aziridine ring of mitomycin C at guanine nucleobase of DNA
Authors: Karim, Murshida
Sarma, Rajib L
Medhi, C
Keywords: Aziridine ring
DNA
ab initio
Mitomycin C
Mitomycin A
Alkylation
Issue Date: Jun-2008
Publisher: CSIR
Abstract: The aziridine ring of mytomycin C interacts with guanine nucleobase of DNA in the alkylation reaction In this context the activation of aziridine ring at the intermediate state may be analysed for understanding the various steps in the overall mechanism when aziridine may target directly the guanine nucleobase or after ring opening. Here, it is shown that aziridine ring opening is an important step in alkylation reaction.
Page(s): 892-902
ISSN: 0376-4699
Source:IJC-B Vol.47B(06) [June 2008]

Files in This Item:

File Description SizeFormat
IJCB 47B(6) 892-902.pdf215.09 kBAdobe PDFView/Open
 Current Page Visits: 555 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 576673 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in