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Title: Theoretical studies on the initiation of alkylation pathway by aziridine ring of mitomycin C at guanine nucleobase of DNA
Authors: Karim, Murshida
Sarma, Rajib L
Medhi, C
Keywords: Aziridine ring;DNA;ab initio;Mitomycin C;Mitomycin A;Alkylation
Issue Date: Jun-2008
Publisher: CSIR
Abstract: The aziridine ring of mytomycin C interacts with guanine nucleobase of DNA in the alkylation reaction In this context the activation of aziridine ring at the intermediate state may be analysed for understanding the various steps in the overall mechanism when aziridine may target directly the guanine nucleobase or after ring opening. Here, it is shown that aziridine ring opening is an important step in alkylation reaction.
Page(s): 892-902
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(06) [June 2008]

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