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|Title:||Theoretical studies on the initiation of alkylation pathway by aziridine ring of mitomycin C at guanine nucleobase of DNA|
Sarma, Rajib L
|Keywords:||Aziridine ring;DNA;ab initio;Mitomycin C;Mitomycin A;Alkylation|
|Abstract:||The aziridine ring of mytomycin C interacts with guanine nucleobase of DNA in the alkylation reaction In this context the activation of aziridine ring at the intermediate state may be analysed for understanding the various steps in the overall mechanism when aziridine may target directly the guanine nucleobase or after ring opening. Here, it is shown that aziridine ring opening is an important step in alkylation reaction.|
|Appears in Collections:||IJC-B Vol.47B(06) [June 2008]|
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