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Title: Synthesis of some novel 1, 2, 4-triazolo [4, 3-a]2H-pyrano [3, 2-e] pyridine derivatives
Authors: Kumar, N Vasanth
Mashelkar, Uday C
Keywords: Pyranopyridine
Antihypertensive activity
Issue Date: May-2008
Publisher: CSIR
Abstract: Substituted 2H-pyrano[3, 2-e][1,2,4]triazolo[4,3-a]pyridine 3a-f and 4a-b have been prepared starting from 5-methyl-6-cyano-7-hydrazino-2-oxo-2H-pyrano[2,3-b] pyridine-3-carboxylic acid 2. The compound 2 is prepared by reacting ethyl-5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano [2,3-b]pyridine-3-carboxylate 1 with hydrazine hydrate at room temperature with good yield. Condensation of 2 with acids results in the formation of 1-substituted 2H-pyrano[3,2-e][1,2,4]triazolo[4,3-a]pyridine (3a-f), further the hydrazine derivative 2 has been transformed to 1-aryl-2H-pyrano[3,2-e][1,2,4]triazolo[4,3-a]pyridine (4a-b). These compounds are expected to have antihypertensive activity.
Description: 764-766
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(05) [May 2008]

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