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Title: Synthesis of some 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H[1,3]thiazolo[3,2-a]-pyrimidin-5-ones
Authors: Kumar, P Vijaya
Reddy, K Manoher
Rao, V Rajeswar
Keywords: Benzopyran-2-one
Pyrimidin-5-ones
Thiazoles
Thiazolo pyrimidones
Issue Date: May-2008
Publisher: CSIR
Abstract: Reaction of 3-(2-amino-4-thiazolyl)coumarins with ethyl acetoacetate in a mixture of PPA and POCl₃ give 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H-thiazolo[3,2-a]pyrimidin-5-ones in a single step. Alternatively condensation of 3-(2-amino-4-thiazolyl)coumarins 1 with acetoacetic ester (EAA) 2 results in the formation of Schiff bases 3a-g. These on further reaction with polyphosphoric acid (PPA) and phosphorus oxychloride (POCl₃) give corresponding cyclised compounds. 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H[1,3]thiazolo[3,2-a]pyrimidin-5-ones 4a-g. The structures of newly prepared compounds have been confirmed from analytical and spectral data.
Page(s): 759-763
ISSN: 0376-4699
Source:IJC-B Vol.47B(05) [May 2008]

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