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|Title:||Synthesis of some 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H[1,3]thiazolo[3,2-a]-pyrimidin-5-ones|
|Authors:||Kumar, P Vijaya|
Reddy, K Manoher
Rao, V Rajeswar
|Abstract:||Reaction of 3-(2-amino-4-thiazolyl)coumarins with ethyl acetoacetate in a mixture of PPA and POCl₃ give 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H-thiazolo[3,2-a]pyrimidin-5-ones in a single step. Alternatively condensation of 3-(2-amino-4-thiazolyl)coumarins 1 with acetoacetic ester (EAA) 2 results in the formation of Schiff bases 3a-g. These on further reaction with polyphosphoric acid (PPA) and phosphorus oxychloride (POCl₃) give corresponding cyclised compounds. 7-methyl-3-(2-oxo-2H-chromen-3-yl)- 5H[1,3]thiazolo[3,2-a]pyrimidin-5-ones 4a-g. The structures of newly prepared compounds have been confirmed from analytical and spectral data.|
|Appears in Collections:||IJC-B Vol.47B(05) [May 2008]|
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