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IJC-B Vol.47B [2008] >
IJC-B Vol.47B(05) [May 2008] >


Title: Synthesis of novel naphtho[2,1-b]furo[3,2-b]pyridine derivatives as potential antimicrobial agents
Authors: Ramesh, D
Chandrashekhar, C
Vaidya, V P
Keywords: Naphthofuran
Naphthofuropyridine
Thrope-Zielger reaction
Friedlander reaction
Antimicrobial activity
Issue Date: May-2008
Publisher: CSIR
Abstract: The starting materials 2-acyl-3-aminonaphtho[2,1-b]furans 4a-b have been directly synthesized from 2-hydroxy-1-naphthaldehyde oxime by treating with α-haloketone through Thrope-Ziegler reaction. The compounds 4a-b undergo Friedlander cyclization on treatment with active methylene compounds, and produce title compounds 5a-b, 6a-b and 7a-b. Some other routes for the synthesis of various derivatives of this new heterocycle have been investigated. All the newly synthesized compounds are characterized by elemental analysis, spectral studies, and have been evaluated for antimicrobial activity.
Page(s): 753-758
ISSN: 0376-4699
Source:IJC-B Vol.47B(05) [May 2008]

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