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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(05) [May 2008] >
| Title: | Synthesis of some new 10H-pyrido[3,2-b][1,4]benzothiazine and their ribofuranosides as possible chemotherapeutic agents |
| Authors: | Kumar, Naresh
Yadav, Ashok K |
| Keywords: | 10H-Pyrido[3,2-b][1,4]benzothiazine
Ribofuranosides
IR
NMR spectra
Antimicrobial activity |
| Issue Date: | May-2008 |
| Publisher: | CSIR |
| Abstract: | N-(2´,3´,5´-tri-O-benzoyl-β-D-ribofuranosyl)-8-chloro-7-methyl/7,9-dimethyl/8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine have been synthesized by the treatment of 10H-8-chloro-7-methyl/ 7,9-dimethyl/8-chloro-9-methyl-3-nitropyrido[3,2-b][1,4]benzothiazines-with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in toluene. Compounds 10H-8-chloro-7-methyl/7,9-dimethyl/8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine and 10-acetyl-8-chloro-7-methyl/7,9-dimethyl/ 8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine-5-oxide have been synthesized. The structure of all the synthesized compounds have been established by elemental analysis, IR and ¹H NMR spectral data. All the synthesized heterocyclic compounds and their ribofuranosides have been screened for their antibacterial and antifungal activity. |
| Page(s): | 748-752 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(05) [May 2008]
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