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Title: Synthesis of some new 10H-pyrido[3,2-b][1,4]benzothiazine and their ribofuranosides as possible chemotherapeutic agents
Authors: Kumar, Naresh
Yadav, Ashok K
Keywords: 10H-Pyrido[3,2-b][1,4]benzothiazine;Ribofuranosides;IR;NMR spectra;Antimicrobial activity
Issue Date: May-2008
Publisher: CSIR
Abstract: N-(2´,3´,5´-tri-O-benzoyl-β-D-ribofuranosyl)-8-chloro-7-methyl/7,9-dimethyl/8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine have been synthesized by the treatment of 10H-8-chloro-7-methyl/ 7,9-dimethyl/8-chloro-9-methyl-3-nitropyrido[3,2-b][1,4]benzothiazines-with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in toluene. Compounds 10H-8-chloro-7-methyl/7,9-dimethyl/8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine and 10-acetyl-8-chloro-7-methyl/7,9-dimethyl/ 8-chloro-9-methyl-3-nitro pyrido[3,2-b][1,4]benzothiazine-5-oxide have been synthesized. The structure of all the synthesized compounds have been established by elemental analysis, IR and ¹H NMR spectral data. All the synthesized heterocyclic compounds and their ribofuranosides have been screened for their antibacterial and antifungal activity.
Page(s): 748-752
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(05) [May 2008]

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