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Title: Potentiality of a new compound for in vitro differentiation between halophilic and non-halophilic vibrios
Authors: Ray, R
Das, A K
Dutta, N K
Chakrabarty, A N
Chaudhuri, B N
Seth, S
Dastidar, Sujata G
Issue Date: Feb-2002
Publisher: NISCAIR-CSIR, India
Abstract: Sensitivity of 21 halophilic vibrios and 16 clinical isolates of non-halophilic vibrios was determined against a new possible antivibrio agent, a pyrimidine analogue, 4, 6-dimethylpyrimidine -2-thiol (4,6-DMPT). It appeared to be a vibriocidal agent, having a mean MIC and MBC of 32 μg/ml for halophilic strains and 64 μg/ml for non-halophilic strains and an LD50of 300 mg/Kg body weight of mice. Thus, 4,6-DMPT may help an in vitro distinction between halophilic and non-halophilicvibrios. Sensitivity of these strains was also studied with respect to pteridine, crystal violet and Tween 80 hydrolysis as further markers distinguishing between these 2 groups which could also be differentiated by their growth on TCBS or/and CLED media.
Page(s): 220-222
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(02) [February 2002]

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