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Title: Changes in lipid peroxidation and free radical scavengers in kidney of hypothyroid and hyperthyroid rats
Authors: Sawant, Bilvadaa U
Nadkarni, Ganeshsunder D
Thakare, Usha R
Joseph, Lebana J
Rajan, M G R
Keywords: Antioxidant enzymes;Free radical scavengers;Hyperthyroidism;Hypothyroidism;Kidney;Lipid peroxidation;Rats
Issue Date: Nov-2003
Publisher: NISCAIR-CSIR, India
Abstract: Kidney weight was significantly decreased in hypothyroidism (induced by Na131I administration) and increased in hyperthyroidism (induced by thyroxine treatment) as compared to control in female Wistar rats. The tissue lipid perox idation level remained unchanged in hyperthyroid rats but significantly increased in hypothyroid rats. Superoxide dismutase was decreased in both experimental groups but more so in hyperthyroid rats. Catalase was reduced significantly in hyperthyroid rats but remained unaffected in hypothyroid rats. Tissue glutathione peroxidase (GPx) activity was increased while reduced glutat hione levels remained unaltered in both hypothyroid and hyperthyroid rats. Plasma GPx activity was significantly low in both the hypothyroid and hyperthyroid rats. The results suggest alterations in the oxidative stress in hypothyroid and hyperthyroid rat kidneys with concomitant changes of free radical scavengers.
Page(s): 1334-1337
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(11) [November 2003]

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