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Title: Modulatory influence of Brassica compestris Linn var sarson on phase-II carcinogen metabolizing enzymes and glutathione levels in mice
Authors: Qiblawi, Samir
Khan, A K
Rao, A R
Prashar, R
Kumar, Ashok
Keywords: Brassica compestris;Carcinogen;Glutathione;Modulatory influence
Issue Date: Nov-2003
Publisher: NISCAIR-CSIR, India
Abstract:   The present study reports the modulatory influence of 95% ethanolic extract from the seeds of B. Compestris on the activity of phase- II enzymes such as glutathione S-transferase (GST), DT-diaphorase (DTD) and reduced glutathione (GSH) level in the skin, lung, kidney and forestomach of the mouse. Oral treatment with the seed extract at 800 mg/kg body wt. For 15 days significantly elevated GST in lung and forestomach and DT-diaphorase in rorestomaeh and skin and GSH level in lung, kidney forestomach and skin. The lower dose 400 mg/kg body wt was effective only in inducing GST and DTdiaphorase activity in forestomach and reduced glutathione level in lung. The findings suggest that B. Compestris seed extract may block or suppress the events associated with chemical carcinogenesis at least in part, by inducing metabolic detoxification of the carcinogen.
Page(s): 1317-1321
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(11) [November 2003]

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