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Title: Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm
Authors: Kulkarni, Shrinivas K
Patil, Chandrashekhar S
Jain, Naveen K
Singh, Amarjit
Keywords: Antispasmodic effect;Guinea pig ileum;Analgesies
Issue Date: Jun-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.7 A61
Abstract: Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of smooth muscle. Diclofenac, in varying concentration (9.4 x 10-5 mol/l and 14.1 x 10-5 mol/l) shifted the concentration response curve of acetylcholine to the right without sppressing the maximal response. However, in higher concentration diclofenac (18.9 x 10-5 mol/l) blocked the response in an unsurmountable fashion. Further, analgin (11.09 x 10-5 , 16.63 x 10-5 and 22. 18 x 10-5 mol/l) in equimolar concentrations did not alter the concentration response curve of acetylcholine, but in higher concentration analgin (44.36 x10-5 mol/l) also blocked the response in an unsurmountable fashion. Pitofenone (2 .5 x 10-6mol/l) also, shifted the concentration response curve of acetylcholine to right in a parallel fashion with no change in maximal response. The present study confirms the potent antispasmodic activity of diclofenac-pitofenone combination in comparison to analgin –pitofcnone in molar equivalcnt concentration (in comparison to diclofenac) against acetylcholine-induced contractions of guinea pig ileum.
Page(s): 567-569
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(06) [June 2004]

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