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Title: Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver
Authors: Anilakumar, K R
Khanum, Farhath
Sudarshanakrishna, K R
Santhanam, K
Keywords: Amaranth leaf;Antioxidant;Liver;Multicomponent antioxidant system;Rat
Issue Date: Jun-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int Cl7 A61K
Abstract: Effect of prefeeding dehydrated amaranth (A. gangeticus) leaves at 10 and 20% levels on a chemical toxicant, dimethylhydrazine (DMH)-induced free radical stress in rat liver was evaluated. DMH-induced rise in hepatic malondialdehyde (MDA), was diminished by AL. AL intake resulted in a significant increase in hepatic glutathione (GSH). The feeding of AL at 10%level increased the hepatic glucose-6- phosphate dehydrogenase (G-6-PDH) activity, while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. Amaranth leaves at 10 and 20% levels of feeding diminished the hepatic superoxide dismutase and glutathione peroxidase (GSH-Px) activities. DMH influenced adversely the hepatic antioxidant enzyme activities. Simultaneous administration of  DMH and feeding of AL enhanced the DMH-induced decrease in hepatic GSH-Px. DMH enhanced formation of micronuclei was reverted significantly by AL intake. Hence, it was concluded that the consumption of AL at 20% level reduced DMH-induced impaired antioxidant status in rat liver.
Page(s): 595-600
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(06) [June 2004]

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