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Title: Design, synthesis and neuropharmacological activity of dihydro imidazole derivatives
Authors: Mariappan, G
Alam, Sadrul
Sutharson, L
Haldar, P K
Nath, Shyamalendu
Keywords: Dihydroimidazole;Anticonvulsant;CNS depressant;Nasal decongestant
Issue Date: Apr-2013
Publisher: NISCAIR-CSIR, India
Abstract: A new series of dihydro imidazole derivatives have been synthesized and characterized by UV-Vis, IR, 1H NMR and mass spectroscopy. The synthesized compounds have been screened for neuro pharmacological activities. All the compounds are effective; amongst them compound 8 shows more prominent anticonvulsant and CNS depressant property. The standard drug diazepam at 25 mg / kg i.p. has been used for comparison. The results are statistically treated for their significance at p<0.05 and p<0.01 level.
Page(s): 568-572
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(04) [April 2013]

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