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Title: Seven-membered ring azasugars as glycosidase inhibitors and anticancer agents
Authors: Lohray, B B
Bhushan, Vidya
Prasuna, G
Jayamma, Y
Raheem, M A
Papireddy, P
Umadevi, B
Premkumar, M
Lakshmi, N S
Narayanareddy, K
Issue Date: Dec-1999
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of various C2 symmetrical tetrahydroxyazepanes has been reported by the reaction of bisepoxides with various primary amines. The tetrahydroxyazepanes inhibit β-glucosidases in micromolar range and also exhibit anticancer activity in various cancer cell lines with GI50 values in the range of 2 to 9×10-5 M. The azepanes are poor inhibitors of HIV protease and their IC50 values are in the range 2×10-4 M.
Page(s): 1311-1321
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.38B(12) December 1999]

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