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|Title:||Seven-membered ring azasugars as glycosidase inhibitors and anticancer agents|
|Authors:||Lohray, B B|
Raheem, M A
Lakshmi, N S
|Abstract:||Synthesis of various C2 symmetrical tetrahydroxyazepanes has been reported by the reaction of bisepoxides with various primary amines. The tetrahydroxyazepanes inhibit β-glucosidases in micromolar range and also exhibit anticancer activity in various cancer cell lines with GI50 values in the range of 2 to 9×10-5 M. The azepanes are poor inhibitors of HIV protease and their IC50 values are in the range 2×10-4 M.|
|Appears in Collections:||IJC-B Vol.38B(12) December 1999]|
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