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|Title:||An efficient method to chiral β-hydroxy acids: Synthesis of lipid-A side chain|
|Abstract:||The synthesis of optically active β-hydroxy acids 5a-c is achieved in four steps from their corresponding terminal olefins 1a-c by employing Sharpless asymmetric dihydroxylation. The regioselective ring opening of chiral cyclic sulfites 3a-c with cyanide ion, constitutes the key reaction, thus producing the hydroxy nitriles 4a-c.|
|Appears in Collections:||IJC-B Vol.38B(08) [August 1999]|
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