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|Title:||Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats|
Siva, Ganesan Vijaiyan
|Keywords:||Antioxidants;Ethanol;High fat diet;Inflammation;Pancreatitis;Thymoquinone|
|Abstract:||A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1β and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.51(04) [April 2013]|
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