Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/16475
Title: Synthesis and reactions of some new 5-aryl-3-oxo-7 -(4'-aryl-2' ,5 '-dioxo-1', 2' ,3 ', 4'-tetrahydrofluoren-3'-yl)-5H, 8H-2,3- dihydrothiazolo[5,4-b]pyrimidines of expected biological activity
Authors: Salama, M A
EI-Essa, S A
Issue Date: Jun-1999
Publisher: NISCAIR-CSIR, India
Abstract: 2-Arylidene-indane-1,3-dione 1 on treatment with acetyl acetone in gl. acetic acid gives 3-acetyl-4-aryl-2,5-dioxo-1,2,3,4- tetrahydrofluorenes 2a-d which on reaction with benzaldehyde yield 4-aryl-3-cinnamoyl-2, 5-dioxo-1, 2, 3, 4-tetrahydrofluorenes 3a-d. Compounds 3a-d when reacted with thiourea in gl. CH3COOH/Ac2O in the presence of anhyd. sodium acetate afford 4,5-diaryl-6-(4'-aryl-2', 5' -dioxo-1', 2', 3', 4'-tetrahydrofluoren- 3'-yl)-1, 2, 3, 4-tetrahydropyrimidine-2-thiones 4a-d which on treatment with chloroacetic acid furnish 5-aryl-3-oxo-7-(4'-aryl- 2', 5' -dioxo-1',2',3',4' -tetrahydrofluoren-3'-yl)-5H, 8H-2,3-dihydrothi azolo[5,4-b]pyrimidines 5a-d. Compounds 5a-d on condensation with benzaldehyde yield 2-arylmethylene-3-oxo-Sphenyl-7-(4' -aryl-2', 5' -dioxo-1',  2', 3', 4'-tetrahydrotluoren-3'yl)-5H, 8H-2,3-dihydrothiazolo[5,4- b ]pyrimidines 6a-d.
Page(s): 739-742
URI: http://hdl.handle.net/123456789/16475
Appears in Collections:IJC-B Vol.38B(06) [June 1999]

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