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|Title:||Synthesis of 5,7,4'-trihydroxy-6-C-prenylflavone|
|Authors:||Hossain, M Amzad|
|Abstract:||5,7,4'-Trihydroxy-6-C-prenylflavone 6 isolated from the fruits of Maclura pomifera has been synthesized by the following route. Phloroacetophenone 1 on treatment with methoxymethyl chloride afford 2-hydroxy-4,6-di(methoxymethoxy) acetophenone 2 which on nuclear prenylation yield 2-hydroxy-4,6-di(methoxymethoxy)-5-C-prenylacetophenone 3 and several other minor products. The methoxymethylated product 3 on condensation with p-hyd roxybenzaldehyde gives the chalcone 4. DDQ (2,3 –dichloro-5, 6-dicyano-1,4-benzoquinone) treatment of 4 afford the compound 5 which upon demethoxymethylation furnish the title compound 6.|
|Appears in Collections:||IJC-B Vol.38B(05) [May 1999]|
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