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|Title:||Synthesis of 7-hydroxy-6,8-di-C-prenylflavanone|
|Authors:||Hossain, M Amzad|
Salehuddin, S M
|Abstract:||The synthesis of flavanone A 8, a constituent of the leaves and bark of Milletia ovalifolia is described. β-Resacetophenone 1 on treatment with methoxymethyl chloride afford 2,4-dimethoxymcthoxyacctophenone 2 which on nuclear prenylation yield 2,4- dimethoxymcthoxy-3 ,5-di-C-prenylacetophenone 5. Alkaline condensation of 5 with benzaldehyde give 2',4'-dimethoxymethox y-3',5' -di-C-prenylchalcone 6. 2',4'-Dihydroxy-3',5'-di–C-prenylchalcone 7 obtained by the demethoxymethylation of 6, on treatment with NaOAc/EtOH furnish 7-hydroxy-6,8-di-C-prenylflavanone (8, flavanone A).|
|Appears in Collections:||IJC-B Vol.38B(05) [May 1999]|
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