Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/16423
Title: Synthesis of 3',5,7-trihydroxy-6",6"-dimethylpyrano[2", 3" : 4', 5']f1avanone
Authors: Hossain, M Amzad
Issue Date: Apr-1999
Publisher: NISCAIR-CSIR, India
Abstract: 3',5, 7-Trihydroxy-6", 6"-dimethylpyrano[2", 3" : 4' , 5']flavanone 7 isolated from the chloroform extract of Erythrina sigmoidea has been synthesized. Methoxymethylation of phloroacetophenone 1 using methoxymethyl chloride and K2Co3 yields compound 2. 3, 4-Dihydroxybenzaldehyde on treatment with 2-chloro-2-methylbut-3-yne in dry dioxan affords 3- hydroxy-6',6'-dimethylpyrano[2', 3' : 4, 3]benzaldehyde 3 which on methoxymethylation yields compound 4. Alkaline condensation of 2 and 4 furnishes 2',4',6', 3- tetra(methoxymethoxy)-6", 6"-dimethylpyrano[2", 3" : 4, 5]chalcone 5. NaOAc/EtOH treatment of 2',4',6', 3-tetrahydroxy-6", 6"-dimethylpyrano[2", 3" : 4, 5]chalcone 6 obtained by the demethoxyrnethylation of 5 furnishes the title compound 7.
Page(s): 427-430
URI: http://hdl.handle.net/123456789/16423
Appears in Collections:IJC-B Vol.38B(04) [April 1999]

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