Please use this identifier to cite or link to this item:
|Title:||Synthesis and antimicrobial activity of 1,8- naphthyridinyl-4-thiazolidinones/1,3-thiazin- 4-ones/2-azetidinones|
Reddy, P Raghotham
Babu Rao, R
|Abstract:||Condensation of 2-aminonicotinaldehyde 1 with p-acetamido-acetophenone 2 affords 2-(p-acetamidophenyl)-1,8-naphthyridine 3, which on acidic hydrolysis yields 2-(p-aminophenyl)-1,8- naphthyridine 4. The amino compound 4 undergo condensation with aromatic aldehydes to give corresponding 2-(p-arylideneaminophenyl)- 1,8-naphthyridines 5. Cyclocondensation of 5 with mercaptoacetic acid and β-mercaptopropionic acid separately in DMF in the presence of anhyd. ZnCI2 results in the formation of 1,8-naphthyridinyl-4- thiazolidinones 6 and 1,8- naphthyridinyl- 1,3-thiazin-4-ones 7, respectively. On the other hand, the arylidene derivatives 5 on cycloaddition with chloroacetyl chloride in the presence of triethylamine in dry 1,4-dioxane furnishes the desired 1,8-naphthyridinyl-2-azetidinones 8. The structures of the compounds 3-8 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data. Some of the compounds have been screened for their antibacterial and antifungal activities.|
|Appears in Collections:||IJC-B Vol.38B(04) [April 1999]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.