Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/16184
Title: Chemo-enzymatic synthesis of chiral 3-hydroxy-azetidin-2-ones
Authors: Bari, S S
Madan, S
Sethi, M K
Issue Date: Jan-1999
Publisher: NISCAIR-CSIR, India
Abstract: n-Tributyltin hydride reduction of 3-acetoxy-4,4-bis(alkylthio)-azetidin-2-ones 4a and 4b produces 4-unsubstituted azetidinone 5 and 4-alkylthio-azetidin-2-one 9 respectively. Azetidin-2,3-diones 8,11,13 which can be conveniently prepared by basic hydrolysis of 3-acetoxy-azetidin-2-ones 5,9,4c followed by oxidation, on biocatalytic reduction with fermenting and immobilised Baker's Yeast in aqueous and organic media, respectively affords chiral 3-hydroxy-azetidin-2- ones 6,10,12,14 with high level of enantioselectivity.
Page(s): 10-17
URI: http://hdl.handle.net/123456789/16184
Appears in Collections:IJC-B Vol.38B(01) [January 1999]

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