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|Title:||Chemo-enzymatic synthesis of chiral 3-hydroxy-azetidin-2-ones|
|Authors:||Bari, S S|
Sethi, M K
|Abstract:||n-Tributyltin hydride reduction of 3-acetoxy-4,4-bis(alkylthio)-azetidin-2-ones 4a and 4b produces 4-unsubstituted azetidinone 5 and 4-alkylthio-azetidin-2-one 9 respectively. Azetidin-2,3-diones 8,11,13 which can be conveniently prepared by basic hydrolysis of 3-acetoxy-azetidin-2-ones 5,9,4c followed by oxidation, on biocatalytic reduction with fermenting and immobilised Baker's Yeast in aqueous and organic media, respectively affords chiral 3-hydroxy-azetidin-2- ones 6,10,12,14 with high level of enantioselectivity.|
|Appears in Collections:||IJC-B Vol.38B(01) [January 1999]|
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