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Title: Antimalarial activity and clinical safety of traditionally used Nyctanthes arbor-tristis Linn.
Authors: Karnik, SR
Tathed, PS
Antarkar, DS
Gidse, CS
Vaidya, RA
Vaidya, ADB
Keywords: Antimalarial activity
Ayurvedic drugs
Traditional medicine
Nyctanthes arbor-tristis Linn
Visham jwara
Issue Date: Apr-2008
Publisher: CSIR
IPC CodeInt. Cl.⁸ : A61K36/00, A61P29/00, A61P33/06
Abstract: Traditional systems of medicine, such as Ayurveda and Chinese medicine in Asia have been provided novel concepts and modalities for healthcare. Critical bedside observations by astute physicians have been followed up by systematic trans-disciplinary research. Such clinical hits of novel biodynamic actions can lead to new drug candidates. In the study, this path was taken up to document antimalarial activity of Nyctanthes arbor-tristis Linn. (Parijat). Nyctanthes arbor-tristis Linn., a popular plant with fragrant flowers described in Ayurveda is being sporadically used for malaria by several Ayurvedic physicians. Patients with malaria were treated with the paste of five fresh leaves of Nyctanthes arbor-tristis Linn, Given orally three times in a day for 7-10 days. The relief of symptoms and signs of malaria and the features of Visham jwara were graded basally and daily. Of 120 patients, ninety two (76.7%) showed complete clinical and parasitic cure within 7 days. Other 20 patients, who then continued on the same treatment, were cured by 10 days. Those patients who did not respond clinically and by parasite clearance were treated with standard antimalarial therapy. Parasite clearance was gradual and showed a direct temporal relationship with the level of initial parasitemia. The paste was well tolerated and no severe side effects were reported. Nyctanthes arbor-tristis Linn, with the dose used showed significant clinical antimalarial activity and good tolerability. A standardized formulation has to be prepared for further studies with critical markers of disease severity as well as parasite clearance.
Page(s): 330-334
ISSN: 0972-5938
Source:IJTK Vol.07(2) [April 2008]

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