Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/15936
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dc.contributor.authorShiju, TM-
dc.contributor.authorRajkumar, R-
dc.contributor.authorRajesh, NG-
dc.contributor.authorViswanathan, Pragasam-
dc.date.accessioned2013-02-11T16:42:35Z-
dc.date.available2013-02-11T16:42:35Z-
dc.date.issued2013-02-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/15936-
dc.description139-148en_US
dc.description.abstractTo investigate the nephroprotective effect of garlic and elucidate the mechanism by which it prevents the progression of diabetic nephropathy in diabetic rats, diabetes was induced by a single ip injection of streptozotocin (45 mg/kg body weight). Garlic extract (500 mg/kg body weight) and aminoguanidine (1 g/L) were supplemented in the treatment groups. Histopathological examination using H&E, PAS staining and the immunohistochemical analysis of vascular endothelial growth factor (VEGF) and extracellular signal-regulated kinase-1 (ERK-1) expression were performed on kidney sections at the end of 12 weeks. Significant change in both, the urine and serum biochemistry confirmed kidney damage in diabetic animals which was further confirmed by the histological changes such as mesangial expansion, glomerular basement membrane thickening, glycosuria and proteinuria. However, the diabetic animals treated with garlic extract showed a significant change in urine and serum biochemical parameters such as albumin, urea nitrogen  and creatinine  compared to that of diabetic rats. Further, the garlic supplemented diabetic rats showed a significant decrease in the expression of VEGF and ERK-1 compared to diabetic rats, attenuating mesangial expansion and glomerulosclerosis. Thus, garlic extract rendered nephroprotection in diabetic rats. en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.51(02) [February 2013]en_US
dc.subjectDiabetesen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectGarlic extracten_US
dc.subjectHypolipidemicen_US
dc.subjectNephroprotectanten_US
dc.titleAqueous extract of Allium sativum L bulbs offer nephroprotection by attenuating vascular endothelial growth factor and extracellular signal-regulated kinase-1 expression in diabetic ratsen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.51(02) [February 2013]

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