Electrochemical synthesis of 2-amino-5-substituted-1,3,4-oxadiazole derivatives and evaluation of antibacterial activity

Abstract

Some new 2-amino-5-substituted-1,3,4-oxadiazoles have been synthesized at platinum electrode through the electrochemical oxidation of semicarbazone at room temperature and studied for their antibacterial activity. This is an environmentally benign method in the field of electroorganic synthesis under controlled potential electrolysis in an undivided cell. The electrolysis have been carried out in the acetonitrile solvent and lithium perchlorate is used as a supporting electrolyte. Two platinum plates are used as working as well as counter electrode and saturated calomel electrode as the reference electrode. These compounds have been characterized by microanalyses, IR, Mass, ¹H NMR and ¹³C NMR spectral data. All the compounds have been evaluated for their antibacterial activity against <i style="mso-bidi-font-style:normal">Klebsilla penumoniae</i>,<i style="mso-bidi-font-style:normal"> Escherichia coli</i>,<i style="mso-bidi-font-style:normal"> Streptococcus aureus</i> and <i style="mso-bidi-font-style:normal">Shigella dysenteriea</i> at 25 and 50 ppm concentrations.