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Title: IgG binding and expression of its receptor in rat intestine during postnatal development
Authors: Gill, Ravinder Kaur
Mahmood, Safrun
Sodhi, C P
Nagpaul, J P
Mahmood, Akhtar
Issue Date: Aug-1999
Publisher: NISCAIR-CSIR, India
Abstract: The hinding of 1251 labelled IgG to the microvillus membranes (MVM) has been studied during postnatal development of rat intestine. The levels of mRNA encoding IgG receptor were also analyzed by liquid hybridization under these conditions. The IgG hinding to MVM reached maximum levels by day 12 and showed a gradual decline upon weaning. The FcRn mRNA was markedly low in adult rats and was maximum during second week or postnatal development. Administration of cortisone or thyroxine to suckling rats, induced precocious decline of both IgG binding and the receptor expression. However, insulin administration did not affect the receptor expression. Scatchard an analysis of IgG binding to MVM in cortisone injected pups revealed that the observed inhibit ion in IgG binding was a consequence of a decrease, both in the affinity constant, (- Ka) as well as in the number of receptor sites (n) while thyroxine administration caused a reduction in the number of receptor sites from 2.29 in control to 1.14 nmoles/mg protein in thyroxine injected pups. These observations indicate that expression of IgG receptor during postnatal development is a hormone regulated process.
Page(s): 252-257
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.36(4) [August 1999]

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