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|Title:||Influence of 7β-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: In vitro studies|
Bansal, M P
|Abstract:||Incubation of murine peritoneal macrophages with 7β hydroxycholesterol (7 β -OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7 β -OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system|
|ISSN:||0975-0959 (Online); 0301-1208 (Print)|
|Appears in Collections:||IJBB Vol.38(3) [June 2001]|
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