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Title: Influence of 7β-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: In vitro studies
Authors: Bansal, Geetanjali
Singh, Uma
Bansal, M P
Issue Date: Jun-2001
Publisher: NISCAIR-CSIR, India
Abstract: Incubation of murine peritoneal macrophages with 7β hydroxycholesterol (7 β -OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7 β -OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system
Page(s): 176-179
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.38(3) [June 2001]

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