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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(6) [December 2012] >
| Title: | Anti-inflammatory and antipyretic activities of the ethanolic extract of Shorea robusta Gaertn. f. resin |
| Authors: | Wani, T A
Chandrashekara, H H
Kumar, D
Prasad, R
Sardar, K K
Kumar, D
Tandan, S K |
| Keywords: | Shorea robusta
Resin
Inflammation
Carrageenan
Pyrexia |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Shorea
robusta Gaertn.
f. (Sal) is one of the most important traditional Indian medicinal
plants. The resin of the plant has been used in the treatment of inflammation
in folklore medicine. In the present study, ethanolic extract (70%) of
S. robusta resin (SRE) was
investigated for its anti-inflammatory and antipyretic activities. Acute
inflammation was produced by carrageenan-induced hind paw edema and sub-acute
by cotton pellet-induced granuloma in male Wistar rats. The antipyretic
activity of SRE was studied using Brewer’s yeast-induced pyrexia in rats. The
rats were divided into five groups with five animals in each group.
Group I was treated with vehicle i.e. 1% v/v Tween-80 and served as control.
Groups II to IV were treated with three different doses of SRE (30, 100 and 300
mg/kg orally). Group V was treated with standard drug etoricoxib (10 mg/kg
orally). The anti-inflammatory activity of SRE was assessed by per cent
reduction
in edema volume of carrageenan-induced hind paw edema and by per cent decrease
in granuloma formation in cotton
pellet-induced granuloma test. SRE (100 and 300 mg/kg) produced a significant
reduction in edema volume and decrease in granulation tissue formation in rats.
Significant reduction in pyrexia was observed at all the dose levels of SRE
i.e. 30, 100 and 300 mg/kg. The results of the present study demonstrated
anti-inflammatory and antipyretic activities of S. robusta resin and supported its traditional therapeutic use in
painful inflammatory conditions and fever.
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| Page(s): | 463-467 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(6) [December 2012]
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