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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(6) [December 2012] >
| Title: | Homocysteine in occlusive vascular disease: A risk marker or risk factor |
| Authors: | Bhargava, Seema
Ali, Arif
Manocha, Anjali
Kankra, Mamta
Das, Sabari
Srivastava, Lalit Mohan |
| Keywords: | Homocysteine
Hill’s criteria
Risk marker
Risk factor
Occlusive vascular disease |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | whether it is
just an association (risk marker) or actually a causative factor (risk factor).
To elucidate this, a retrospective statistical analysis was done of data
generated in the course of our study on homocysteine and vascular disease.
Homocysteine, lipid profile components and lipoprotein(a) were estimated in
fasting blood samples drawn from 252 controls and 536 patients of occlusive
vascular disease. The data were analyzed by SPSS version 17. Mean homocysteine
levels were significantly higher (p<0.001) in all patients categories, as
compared to controls. In fact, homocysteine level was the most significant
biochemical risk factor for vascular disease. The odds ratios due to
hyperhomocysteinemia varied from 3.170-4.153. When the cut-off was increased by
5 µmol/L, the odds ratio became almost three-fold. The prevalence of
hyperhomocysteinemia increased by @20%, when the cut-off was reduced by 5
µmol/L. Statistical analysis of our data revealed that homocysteine conformed
to Hill’s criteria of causation. Moreover, hyperhomocysteinemia was treatable
by the administration of B-vitamins, even if the cause was genetic. Hence
morbidity due to vascular disease could be reduced by identification and
treatment of hyperhomocysteinemia.
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| Page(s): | 414-420 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(6) [December 2012]
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