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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(6) [December 2012] >
| Title: | Protective effect of Withania somnifera roots extract on hematoserological profiles against lead nitrate-induced toxicity in mice |
| Authors: | Sharma, Veena
Sharma, Sadhana
Pracheta |
| Keywords: | Withania somnifera
Lead nitrate
Albino mice
Blood profiles |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The in vivo
protective role of hydro-methanolic root extract of Withania somnifera
(WS) was evaluated in alleviating lead nitrate (LN)-induced toxicity in male Swiss albino mice by measuring hematoserological profiles. The lead-treated
(20 mg/kg body wt, p.o.) albino mice (25-30 g) concurrently received the root extract
(200 and 500 mg/kg body wt, p.o.) once daily for the duration of six weeks.
Animals exposed to LN showed significant (P<0.001) decline in haemoglobin
content, red blood cell count, white blood cell count, packed cell volume and
insignificant decrease in mean corpuscular haemoglobin and mean corpuscular
haemoglobin content, while mean corpuscular volume and platelet count were
increased. A significant elevation (P<0.001) in serum glutamate oxaloacetate
transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, acid
phosphatase and total cholesterol were also observed, when compared with
control mice. Thus, the study demonstrated that the concurrent daily
administration of root extract of WS protected the adverse effects of LN
intoxication in mice.
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| Page(s): | 458-462 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(6) [December 2012]
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