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Title: Quantitative structure-activity relationship study on N-(pyridin-4-yl)-(indol-3-yl) alkylamides as antiallergic agents
Authors: Singh, P
Sharma, B K
Kumar, R
Issue Date: Oct-2002
Publisher: NISCAIR-CSIR, India
Abstract: The antihistamine activit y of N-(pyridin -4-yl)-(indol-3 -y l) alkylamides has been analyzed using Fujita-Ban and Hansch approaches. The analyses have helped to ascertain the role of different substituents in explaining the antiallergic actions of these &nbsp;analogues. From both approaches it is revealed that the small size substituents at R and <span style="font-size:14.0pt; font-family:HiddenHorzOCR;mso-bidi-font-family:HiddenHorzOCR">R<sub>2</sub> and non-hydrogen bond acceptor substituent at R improve histamine antagonist activity of a compound. Likewise, a small incision such as - CH<sub>2</sub>CONH-serving as the spacer between pyridinyl and indolyl rings and a bigger substituent like 4-FBn at R<sub>1</sub> are also desirable for inhibitory activity. &nbsp; </span>
Description: 351-355
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.39(5) [October 2002]

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