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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.39 [2002] >
IJBB Vol.39(5) [October 2002] >
| Title: | Quantitative structure-activity relationship study on N-(pyridin-4-yl)-(indol-3-yl) alkylamides as antiallergic agents |
| Authors: | Singh, P
Sharma, B K
Kumar, R |
| Issue Date: | Oct-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The antihistamine activit y of N-(pyridin
-4-yl)-(indol-3 -y l)
alkylamides has been analyzed using Fujita-Ban and
Hansch
approaches. The analyses have helped to ascertain the
role of different substituents in explaining the antiallergic actions of these analogues. From both approaches it is revealed
that the small size substituents at R and R2
and non-hydrogen bond acceptor substituent at R
improve histamine antagonist activity of a compound. Likewise, a small incision
such as - CH2CONH-serving as the spacer between pyridinyl and
indolyl rings and a
bigger substituent like 4-FBn at R1 are also desirable for inhibitory activity.
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| Page(s): | 351-355 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.39(5) [October 2002]
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