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|Title:||Spectrofluorimetric study on inclusion interaction of β-cyclodextrin with duloxetine and its analytical application|
|Keywords:||Analytical chemistry;Spectrofluorimetry;Fluorescence;Inclusion complexes;Duloxetine;β-Cyclodextrin|
|Abstract:||Fluorescence study on inclusion interaction of duloxetine in β-cyclodextrin shows significant increase in the fluorescence of duloxetine in the presence of β-cyclodextrin. The effects of pH and cyclodextrin concentration on the fluorescence spectra are reported. Fluorescence spectroscopy of the host-guest interaction between duloxetine and β-cyclodextrin shows formation of inclusion complex with a 1:1 stoichiometric ratio. The changes in fluorescence of duloxetine on inclusion in the hydrophobic β-cyclodextrin cavity is used to calculate its association constants by non-linear regression method. A new spectrofluorometric method is proposed for quantitative determination of duloxetine in dosage forms with limit of detection of 2.0 × 10-8 mol/L. The linear range is 5.16 × 10-8 mol/L to 1 × 10-5 mol/L and correlation coefficient is 0.9998. The accuracy (recovery 99.5–100.8 %) and precision (RSD 0.58–0.89 %) values of the proposed method are satisfactory.|
|Appears in Collections:||IJC-A Vol.51A(12) [December 2012]|
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