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Title: Spectrofluorimetric study on inclusion interaction of β-cyclodextrin with duloxetine and its analytical application
Authors: Misiuk, Wieslawa
Keywords: Analytical chemistry
Inclusion complexes
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: Fluorescence study on inclusion interaction of duloxetine in β-cyclodextrin shows significant increase in the fluorescence of duloxetine in the presence of β-cyclodextrin. The effects of pH and cyclodextrin concentration on the fluorescence spectra are reported. Fluorescence spectroscopy of the host-guest interaction between duloxetine and β-cyclodextrin shows formation of inclusion complex with a 1:1 stoichiometric ratio. The changes in fluorescence of duloxetine on inclusion in the hydrophobic β-cyclodextrin cavity is used to calculate its association constants by non-linear regression method. A new spectrofluorometric method is proposed for quantitative determination of duloxetine in dosage forms with limit of detection of 2.0 × 10-8 mol/L. The linear range is 5.16 × 10-8 mol/L to 1 × 10-5 mol/L and correlation coefficient is 0.9998. The accuracy (recovery 99.5–100.8 %) and precision (RSD 0.58–0.89 %) values of the proposed method are satisfactory.
Description: 1706-1710
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.51A(12) [December 2012]

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