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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.51A [2012] >
IJC-A Vol.51A(12) [December 2012] >
| Title: | Spectrofluorimetric study on inclusion interaction of β-cyclodextrin with duloxetine and its analytical application |
| Authors: | Misiuk, Wieslawa |
| Keywords: | Analytical chemistry
Spectrofluorimetry
Fluorescence
Inclusion complexes
Duloxetine
β-Cyclodextrin |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Fluorescence
study on inclusion interaction of duloxetine in
β-cyclodextrin shows significant increase in the fluorescence of duloxetine in
the presence of β-cyclodextrin. The effects of pH and cyclodextrin concentration on the fluorescence spectra are
reported. Fluorescence spectroscopy of the host-guest interaction between
duloxetine and β-cyclodextrin shows formation of inclusion complex with a 1:1
stoichiometric ratio. The changes in fluorescence of duloxetine on inclusion in
the hydrophobic
β-cyclodextrin cavity is used to calculate its association constants by
non-linear regression method. A new spectrofluorometric method is proposed for
quantitative determination of duloxetine in dosage forms with limit of
detection of 2.0 × 10-8 mol/L. The linear range is 5.16 × 10-8
mol/L to 1 × 10-5 mol/L and correlation coefficient is 0.9998. The
accuracy (recovery 99.5–100.8 %)
and precision (RSD 0.58–0.89 %) values of the proposed method are satisfactory.
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| Page(s): | 1706-1710 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.51A(12) [December 2012]
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