NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.51A [2012] >
IJC-A Vol.51A(12) [December 2012] >


Title: Theoretical study of inclusion complexation of tricylic antidepressant drugs with β-cyclodextrin
Authors: Jenita, M Jude
Prabhu, A Antony Muthu
Rajendiran, N
Keywords: Theoretical chemistry
Cyclodextrin
Tricyclic antidepressant drugs
Inclusion complex
Molecular recognition
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: The inclusion process of four tricyclic antidepressant drugs (carbamazepine, imipramine, dothiepin and doxepin) with β-cyclodextrin (β-CD), as well as their possible interaction types have been investigated theoretically. The data suggest that these drugs are partially encapsulated into the β-CD cavity. The formation of the inclusion complex is predicted to be an enthalpy-driven process in gas phase. Different interactions between these drugs and β-CD should be also possible due to their negative binding energy though their distributions differ greatly. Comparative study of the interactions of these drugs with β-CD has been investigated and their obvious differences in binding energy and enthalpy change suggest that the β-CD can identify the stability of the complex.
Page(s): 1686-1694
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0975(Online); 0376-4710(Print)
Source:IJC-A Vol.51A(12) [December 2012]

Files in This Item:

File Description SizeFormat
IJCA 51A(12) 1686-1694.pdf248.24 kBAdobe PDFView/Open
 Current Page Visits: 395 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 586854 since 06-Feb-2009  Last updated on 18-Sep-2014Webmaster: nopr@niscair.res.in