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IJC-B Vol.51B(12) December 2012] >

Title: An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug
Authors: Sekharayya, M Chandra
Narayana, G Venkata
Nigam, Satish
Madhusudhan, G
Keywords: Etodolac
2-Ethylphenyl¬hydrazine hydrochloride
Anti-inflammatory drug N,N-dimethylacetamide
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: An improved and scalable method is developed for the synthesis of 7-ethyltryptophol, a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug (NSAID) starting from commercially available 2-ethylphenyl hydrazine and dihydrofuran with H2SO4 as a catalyst in N,N-dimethylacetamide (DMAc)-H2O (1:1) as a solvent in 69% yield. The method is easy, inexpensive and reproducible and the process is clean, high yielding and operationally simple.
Page(s): 1763-1766
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(12) December 2012]

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