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|Title:||An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug|
|Authors:||Sekharayya, M Chandra|
Narayana, G Venkata
Anti-inflammatory drug N,N-dimethylacetamide
|Abstract:||An improved and scalable method is developed for the synthesis of 7-ethyltryptophol, a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug (NSAID) starting from commercially available 2-ethylphenyl hydrazine and dihydrofuran with H<sub>2</sub>SO<sub>4</sub> as a catalyst in <i style="mso-bidi-font-style:normal">N</i>,<i style="mso-bidi-font-style:normal">N</i>-dimethylacetamide (DMAc)-H<sub>2</sub>O (1:1) as a solvent in 69% yield. The method is easy, inexpensive and reproducible and the process is clean, high yielding and operationally simple.|
|Appears in Collections:||IJC-B Vol.51B(12) December 2012]|
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