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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(12) December 2012] >
| Title: | An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug |
| Authors: | Sekharayya, M Chandra
Narayana, G Venkata
Nigam, Satish
Madhusudhan, G |
| Keywords: | Etodolac
7-Ethyltryptophol
2-Ethylphenyl¬hydrazine hydrochloride
Anti-inflammatory drug N,N-dimethylacetamide |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An improved and scalable
method is developed for the synthesis of 7-ethyltryptophol, a key intermediate
for Etodolac, a non-steroidal anti-inflammatory drug (NSAID) starting from
commercially available 2-ethylphenyl hydrazine and dihydrofuran with H2SO4
as a catalyst in N,N-dimethylacetamide (DMAc)-H2O
(1:1) as a solvent in 69% yield. The method is easy, inexpensive and
reproducible and the process is clean, high yielding and operationally simple. |
| Page(s): | 1763-1766 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(12) December 2012]
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