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Title: Acid catalyzed condensation of pyroglutamic acid with arylaldehydes: Synthesis of (3R, 7aS)-3-aryldihydropyrrolo[1, 2-c] oxazol-1, 5(3H, 6H) dione
Authors: Prasad, Jagdish
Panday, Sharad Kumar
Keywords: Pyroglutamic acid;Aromatic aldehyde;Acid catalyzed condensation reaction;Bicyclic derivative
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: A simple strategy for the synthesis of (3R, 7aS)-3-aryldihydro­pyrrolo [1, 2-c] oxazol-1, 5(3H, 6H)-diones as bicyclic hemi­aminals through acid catalyzed condensation of pyroglutamic acid with arylaldehydes has been described. This could be useful for the synthesis of complex natural products requiring α-substitution in proline or pyroglutamate skeleton.
Page(s): 1781-1784
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(12) December 2012]

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