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Title: A mild and efficient synthesis of bis(indolyl)methane derivatives catalyzed by monoammonium salt of 12-tungstophosphoric acid
Authors: Giri, B Y
Devi, B L A Prabhavathi
Vijayalakshmi, K
Prasad, R B N
Lingaiah, N
Prasad, P S Sai
Keywords: Indole;Bis(indolyl)methane;Aromatic aldehydes;Monoammonium salt;12-tungstophosphoric acid [(NH4)H2PW12O40];Heteropolyacid
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: A simple, highly rapid and efficient electophilic substitution reaction of indole with various aromatic aldehydes has been carried out using 5 wt% of monoammonium salt of 12-tungstophosphoric acid [(NH4)H2PW12O40] as a solid acid catalyst in acetonitrile to afford the corresponding bis(indolyl)methanes in excellent yields (84-95%) at room temperature. The heteropolyacid-based catalyst has the advantages of simple workup procedure, water insolubility with good activity and high yielding reaction for the synthesis of bis(indolyl)methane derivatives.
Page(s): 1731-1737
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(12) December 2012]

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