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IJC-B Vol.51B(12) December 2012] >

Title: Conventional and microwave assisted synthesis of new benzotriazole derivatives and their antimicrobial potential
Authors: Shukla, D K
Sen, J P
Jain, A K
Keywords: Benzotriazole
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: The cyclization reaction of 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-substituted arylidene-hydrazino-1′,3′,4′-thiodiazoles (starting material) using thioglycolic acid has afforded the corresponding 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-2′ [2′′-(substi­tuted phenyl)-4′′-oxo-1′′,3′′-thiazolidine]-1′,3′,4′-thiadia­zoles, 1a-k which is further condensed with various aromatic aldehydes in presence of suitable base to yield 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-2′-[5′′-(benzylidene)-2′′-substituted phenyl-4′′-oxo-1′′,3′′-thiazolidine]-1′,3′,4′-thiadiazoles, 2a-k. These compounds have been synthesized by conventional as well as microwave assisted methods and the structures are established on the basis of spectral and analytical data. All the synthesized compounds have been screened for their antimicrobial activities and are found to possess significant antibacterial activity against Bacillus subtillus, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxyporum and Trichoderma viride.
Page(s): 1776-1780
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(12) December 2012]

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