25-May-2013
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(12) December 2012] >
| Title: | Conventional and microwave assisted synthesis of new benzotriazole derivatives and their antimicrobial potential |
| Authors: | Shukla, D K
Sen, J P
Jain, A K |
| Keywords: | Benzotriazole
Thiadiazole
Thiazolidine
Antibacterial
Antifungal |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The cyclization reaction of 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-substituted
arylidene-hydrazino-1′,3′,4′-thiodiazoles (starting material) using
thioglycolic acid has afforded the corresponding
5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-2′ [2′′-(substituted
phenyl)-4′′-oxo-1′′,3′′-thiazolidine]-1′,3′,4′-thiadiazoles, 1a-k which is further condensed with
various aromatic aldehydes in presence of suitable base to yield 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-2′-[5′′-(benzylidene)-2′′-substituted
phenyl-4′′-oxo-1′′,3′′-thiazolidine]-1′,3′,4′-thiadiazoles, 2a-k. These compounds have been synthesized by conventional as
well as microwave assisted methods and the structures are established on the
basis of spectral and analytical data. All the synthesized compounds have been
screened for their antimicrobial activities and are found to possess
significant antibacterial activity against Bacillus
subtillus, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and antifungal
activity against Aspergillus niger, Aspergillus flavus, Fusarium oxyporum and Trichoderma
viride.
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| Page(s): | 1776-1780 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(12) December 2012]
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