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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(12) [December 2012] >
| Title: | Endothelium-dependent and independent vasorelaxant effects of aqueous extract of Tridax procumbens Lin. leaf in rat aortic rings |
| Authors: | Salahdeen, Hussein M
Idowu, Gbolahan O
Murtala, Babatunde A |
| Keywords: | Acetylcholine
Aortic ring
Hypertension
Smooth muscle
Tridax procumbens |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Tridax procumbens leaf extract
induced aortic relaxation in a concentration-dependent manner, for both phenylephrine (PE) and KCl- induced contractions in
isolated rat aortic rings. The relaxation effect of the extract on PE-induced
contraction was 57% greater than that on KCl- induced contraction. The extract caused dose-dependent relaxations in precontracted
isolated rat aorta with phenylephrine; the relaxation
was attenuated by the removal of endothelium. However, the relaxation
responses to sodium nitroprusside were not significantly abolished by the
removal of endothelium.
The vasorelaxatory effect of the extract was completely abolished in presence
of L-NAME. The results indicate that the vasorelaxant effect of T. procumbens extract is probably
mediated by both endothelium-dependent and-independent mechanisms. |
| Page(s): | 883-888 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(12) [December 2012]
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