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Title: <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Endothelium-dependent and independent vasorelaxant effects of aqueous extract of <i style="mso-bidi-font-style:normal">Tridax procumbens</i> Lin. leaf in rat aortic rings</span>
Authors: Salahdeen, Hussein M
Idowu, Gbolahan O
Murtala, Babatunde A
Keywords: Acetylcholine
Aortic ring
Smooth muscle
<i style="mso-bidi-font-style:normal"><span style="font-size:9.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:AR-SA;mso-bidi-font-weight:bold" lang="EN-GB">Tridax procumbens</span></i>
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: <i>Tridax</i><i style="mso-bidi-font-style: normal"> procumbens</i> leaf extract induced aortic relaxation in a concentration-dependent manner, for both phenylephrine (PE) and KCl- induced contractions in isolated rat aortic rings. The relaxation effect of the extract on PE-induced contraction was 57% greater than that on KCl- induced contraction. The extract<i style="mso-bidi-font-style:normal"> </i>caused dose-dependent relaxations in precontracted isolated rat aorta with phenylephrine; the relaxation was attenuated by the removal of endothelium. However, the relaxation responses to sodium nitroprusside were not significantly abolished by the removal of endothelium. The vasorelaxatory effect of the extract was completely abolished in presence of L-NAME. The results indicate that the vasorelaxant effect of <i style="mso-bidi-font-style:normal">T. procumbens </i>extract is probably mediated by both endothelium-dependent and-independent mechanisms.
Description: 883-888
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(12) [December 2012]

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