Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/15174
Title: <span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Protective effects of different extracts of<i style="mso-bidi-font-style:normal"> </i><i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Eucommia ulmoides </span></i><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Oliv<span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:AR-SA" lang="EN-GB">. <span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">against thioacetamide-induced hepatotoxicity in mice</span></span></span></span>
Authors: Zheng, Jie
Yan, Qiuping
Zhang, Kun
Zheng, Yang
Zhao, Suqing
Keywords: Antioxidant activity
<i style="mso-bidi-font-style:normal"><span style="font-size:9.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";color:black;mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Eucommia ulmoides</span></i>
Protective effect
Thioacetamide-induced hepatotoxicity
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: A comparison of analysis in evaluating the hepatoprotective action of fractional ethanolic (F<sub>0</sub>), ethyl acetic (F<sub>1</sub>), n-butanol (F<sub>2</sub>) and aqueous (F<sub>3</sub>) extracts of <i style="mso-bidi-font-style:normal">E. ulmoides</i> Oliv. (EUO) against thioacetamide (TAA) induced hepatic damage was studied in mice. The extract (453 mg/kg-F<sub>0</sub>, 104 mg/kg-F<sub>1</sub>, 95 mg/kg-F<sub>2</sub> and 237 mg/kg-F<sub>3</sub> body weight, po, once daily for 15 days) restored serum marker enzymes levels to normal in TAA treated mice. The biochemical biomarkers viz., total protein, albumin and total bilirubin were also restored forward normal level expression pattern of liver protein profile of mice by using sodium dodecyl sulfate polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis showed 144 spots in TAA administered group which were significantly reduced in EUO extracts treated group. Among the four extracts ethyl acetate (F<sub>1</sub>) and n-butanol (F<sub>2</sub>) extracts showed more significant liver protection. TAA induced injury can be correlated with its high phenolic content in these extracts which may have hepatoprotective effects in regulating liver proteins by scavenging free radicals.
Description: 875-882
URI: http://hdl.handle.net/123456789/15174
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(12) [December 2012]

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