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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(12) [December 2012] >
| Title: | Protective effects of different extracts of Eucommia ulmoides Oliv. against thioacetamide-induced hepatotoxicity in mice |
| Authors: | Zheng, Jie
Yan, Qiuping
Zhang, Kun
Zheng, Yang
Zhao, Suqing |
| Keywords: | Antioxidant activity
Eucommia ulmoides
Protective effect
Thioacetamide-induced hepatotoxicity |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A comparison of analysis in
evaluating the hepatoprotective action of fractional ethanolic (F0),
ethyl acetic (F1),
n-butanol (F2) and aqueous (F3) extracts of E. ulmoides Oliv. (EUO) against
thioacetamide (TAA) induced hepatic damage was studied in mice. The extract (453
mg/kg-F0, 104 mg/kg-F1, 95 mg/kg-F2 and 237 mg/kg-F3
body weight, po, once daily for 15 days) restored serum marker enzymes levels
to normal in TAA treated mice. The biochemical biomarkers viz.,
total protein, albumin and total bilirubin were also restored forward normal
level expression pattern of liver protein profile of mice by using sodium
dodecyl sulfate polyacrylamide gel electrophoresis and two-dimensional gel
electrophoresis showed 144 spots in TAA administered group which
were significantly reduced in EUO extracts treated group. Among the four
extracts ethyl acetate (F1) and n-butanol (F2) extracts showed
more significant liver protection. TAA induced injury can be correlated with
its high phenolic content in these extracts which may have hepatoprotective
effects in regulating liver proteins by scavenging free radicals. |
| Page(s): | 875-882 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(12) [December 2012]
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