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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(12) [December 2012] >
| Title: | Neuropharmcological potential of methanolic extract and a triterpene isolated from Madhuca longifolia L leaves in mice |
| Authors: | Inganakal, Triveni S
Ahmed, Md. Liyakhat
Swamy, Paramjyothi |
| Keywords: | Chlorpromazine
Diazepam
Madhuca longifolia
Madhucic acid
Neuropharmacological effect
Phenobarbitone |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The methanolic extract of M.
longifolia (MLME) and a compound a triterpene, derivative of madhucic acid
(dMA) isolated from the leaves of M. longifolia, were investigated for
their possible neuropharmacological activities in mice using phenobarbitone
induced sleeping time, spontaneous motor activity, marble burying test and
Eddy’s hot plate method. LD50 for MLME and dMA were 100 and 10 mg/kg
of body weight, respectively. Both MLME and dMA (10 mg/kg and 2 mg/kg oral
route respectively) exhibited significant increase in phenobarbitone induced
sleeping time, greater reduction in spontaneous motor activity and marble
burying activity, confirming their sedative nature. Both MLME and dMA also
exhibited considerable antinociceptive activity in experimental animals. The
results suggest that both MLME and dMA have CNS depressant activity in mice. |
| Page(s): | 862-866 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(12) [December 2012]
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