Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/15172
Title: <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Neuropharmcological potential of methanolic extract and a triterpene isolated from <i>Madhuca longifolia L</i> leaves in mice </span>
Authors: Inganakal, Triveni S
Ahmed, Md. Liyakhat
Swamy, Paramjyothi
Keywords: Chlorpromazine
Diazepam
<i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Madhuca longifolia</span></i>
Madhucic acid
Neuropharmacological effect
Phenobarbitone
Issue Date: Dec-2012
Publisher: NISCAIR-CSIR, India
Abstract: The methanolic<b> </b>extract of <i>M. longifolia</i> (MLME) and a compound a triterpene, derivative of madhucic acid (dMA) isolated from the leaves of <i>M. longifolia,</i> were investigated for their possible neuropharmacological activities in mice using phenobarbitone induced sleeping time, spontaneous motor activity, marble burying test and Eddy’s hot plate method. LD<sub>50</sub> for MLME and dMA were 100 and 10 mg/kg of body weight, respectively. Both MLME and dMA (10 mg/kg and 2 mg/kg oral route respectively) exhibited significant increase in phenobarbitone induced sleeping time, greater reduction in spontaneous motor activity and marble burying activity, confirming their sedative nature. Both MLME and dMA also exhibited considerable antinociceptive activity in experimental animals. The results suggest that both MLME and dMA have CNS depressant activity in mice.
Description: 862-866
URI: http://hdl.handle.net/123456789/15172
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(12) [December 2012]

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