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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(11) [November 2012] >
| Title: | Design, synthesis, biological evaluation of thiazolyl schiff base derivatives as novel anti-inflammatory agents |
| Authors: | Bhosale, P P
Chavan, R S
Bhosale, A V |
| Keywords: | Thiazole
Schiff base
Anti-inflammatory activity
Analgesic activity
Ulcerogenic activity |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of new
4-(4-substitutedphenyl)-N-(4-substitutedbenzylidene)-thiazol-2-amine
derivatives 5a-l has been synthesized
and evaluated for their anti-inflammatory and analgesic activities at a dose of
50 mg/kg p.o. The most active compounds 5a, 5j have been subjected to
acute ulcerogenesis study at a dose of 150 mg/kg. The structure of all these
compounds have been established on the basis of spectral (IR, 1H NMR
data) studies. |
| Page(s): | 1649-1654 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(11) [November 2012]
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