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Title: Design, synthesis, biological evaluation of thiazolyl schiff base derivatives as novel anti-inflammatory agents
Authors: Bhosale, P P
Chavan, R S
Bhosale, A V
Keywords: Thiazole;Schiff base;Anti-inflammatory activity;Analgesic activity;Ulcerogenic activity
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   A series of new 4-(4-substitutedphenyl)-N-(4-substituted­benzylidene)-thiazol-2-amine derivatives 5a-l has been synthe­sized and evaluated for their anti-inflammatory and analgesic activities at a dose of 50 mg/kg p.o. The most active compounds 5a, 5j have been subjected to acute ulcerogenesis study at a dose of 150 mg/kg. The structure of all these compounds have been established on the basis of spectral (IR, 1H NMR data) studies.
Page(s): 1649-1654
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(11) [November 2012]

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