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Title: Synthesis, characterization and antimicrobial screening of some novel chalcones and their derivatives
Authors: Chate, Asha V
Joshi, Ratnadeep S
Mandhane, Priyanka G
Gill, Charansingh H
Keywords: Ultrasonication;Chalcone;Chromones;Flavones;Vanillin;Antimicrobial activity
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   Synthesis of some novel 2-(4-(allyloxy)-3-methoxyphenyl)-4H-chromen-4-ones 5a-f and 2-(4-(allyloxy)-3-methoxyphenyl)-3-chloro-4H-chromen-4-ones 6a-f by oxidative cyclisation of (E)-3-(4-allyloxy)-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-ones using DMSO/I2 and DMSO/CuCl2 at reflux condition has been carried out. A useful and efficient synthetic strategy for the synthesis of 4-allyloxy-3-methoxyphenyl chromones has been reported. The synthesized compounds have been characterized by melting point, FT-IR, NMR and EI-MS spectral data. The synthesized compounds have been evaluated for their antibacterial and antifungal activities. Most of the compounds are found to be of comparable potency when compared with the reference standard drugs.
Page(s): 1642-1648
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(11) [November 2012]

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