NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(11) [November 2012] >

Title: Synthesis and antimicrobial activity studies of certain pyrimidinyl oxadiazolo azetidinones
Authors: George, Sonia
Sabitha, R
Govindhammal, V
Ravi, T K
Keywords: Pyrimidinyl oxadiazoles
Antibacterial activity
Antifungal activity
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   Aryl substituted pyrimidinyl oxadiazolo azetidinones have been synthesized from ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 1 which on reaction with semicarbazide hydrochloride in ethanol yields 2-[(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)carbonyl]hydra­zi­ne­carboxamide 2. Compound 2, on reaction with concentrated sulphuric acid, undergo cyclization to yield 5-(5-amino-1,3,4-oxadiazol-2-yl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 3. Further, compound 3, on treatment with appropriate aldehydes, in ethanol give 6-methyl-4-phenyl-5-(5-{[(1E)-aryl­methyl­idene]amino}-1,3,4-oxadiazol-2-yl)-3,4-dihydropyrimidin-2(1H)-ones 4a-e. Finally, the title compounds 5-[5-(3-chloro-2-oxo-4-arylazetidin-1-yl)-1,3,4-oxadiazol-2-yl]-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-ones 5a-e have been obtained by ring closure of the compounds 4a-e with monochloroacetyl chloride in dioxane in the presence of triethylamine. The structures of the novel compounds are assigned based on IR, 1H NMR, mass spectral data and elemental analysis data. All the compounds have been screened for their antimicrobial activity using bacterial and fungal strains.
Page(s): 1637-1641
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(11) [November 2012]

Files in This Item:

File Description SizeFormat
IJCB 51B(11) 1637-1641.pdf65.22 kBAdobe PDFView/Open
 Current Page Visits: 135 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167502 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: