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Title: Facile thermal rearrangement of Lorazepam and Oxazepam
Authors: Siddegowda, Maravanahalli S
Yathirajan, Hemmige S
Ramakrishna, Ramesha A
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   Lorazepam 1, a very well known anti-convulsant undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(o-chlorophenyl)-2-Quinazolinecarboxaldehyde 10 in almost quantitative yield. Oxazepam 2 which is structurally similar, require higher temperature for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde 11. However, structurally similar temazepam 3 did not undergo this rearrangement.
Page(s): 1628-1632
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(11) [November 2012]

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