|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(11) [November 2012] >
| Title: | Facile thermal rearrangement of Lorazepam and Oxazepam |
| Authors: | Siddegowda, Maravanahalli S
Yathirajan, Hemmige S
Ramakrishna, Ramesha A |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Lorazepam 1, a very well known anti-convulsant
undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(o-chlorophenyl)-2-Quinazolinecarboxaldehyde
10 in almost quantitative yield.
Oxazepam 2 which is structurally
similar, require higher temperature
for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde
11. However, structurally similar
temazepam 3 did not undergo this
rearrangement.
|
| Page(s): | 1628-1632 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(11) [November 2012]
|
|
