Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14987
Title: Facile thermal rearrangement of Lorazepam and Oxazepam
Authors: Siddegowda, Maravanahalli S
Yathirajan, Hemmige S
Ramakrishna, Ramesha A
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   Lorazepam <b style="mso-bidi-font-weight:normal">1</b>, a very well known anti-convulsant undergo facile thermal rearrangement at about 110<span style="font-family:Symbol;mso-ascii-font-family:" times="" new="" roman";mso-hansi-font-family:="" "times="" roman";mso-char-type:symbol;mso-symbol-font-family:symbol"="" lang="EN-GB">°C to 6-chloro-4-(<i style="mso-bidi-font-style:normal">o-</i>chlorophenyl)-2-Quinazolinecarboxaldehyde <b style="mso-bidi-font-weight:normal">10</b> in almost quantitative yield. Oxazepam <b style="mso-bidi-font-weight:normal">2 </b>which is structurally similar<b style="mso-bidi-font-weight:normal">,</b> require higher temperature for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde <b style="mso-bidi-font-weight:normal">11</b>. However, structurally similar temazepam <b style="mso-bidi-font-weight:normal">3</b> did not undergo this rearrangement. </span>
Description: 1628-1632
URI: http://hdl.handle.net/123456789/14987
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(11) [November 2012]

Files in This Item:
File Description SizeFormat 
IJCB 51B(11) 1628-1632.pdf73.92 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.