NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(11) [November 2012] >

Title: Facile thermal rearrangement of Lorazepam and Oxazepam
Authors: Siddegowda, Maravanahalli S
Yathirajan, Hemmige S
Ramakrishna, Ramesha A
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   Lorazepam 1, a very well known anti-convulsant undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(o-chlorophenyl)-2-Quinazolinecarboxaldehyde 10 in almost quantitative yield. Oxazepam 2 which is structurally similar, require higher temperature for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde 11. However, structurally similar temazepam 3 did not undergo this rearrangement.
Page(s): 1628-1632
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(11) [November 2012]

Files in This Item:

File Description SizeFormat
IJCB 51B(11) 1628-1632.pdf73.92 kBAdobe PDFView/Open
 Current Page Visits: 127 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167218 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: